Dave thinks the scoping aspect is, or should be, captured in the instance and not in the catalogue. A Syndrome that linked two elements should include a signature term that linked the subjects of the two syndrome instances. This exists in the model currently, so I don't think this need to be an issue. Updates from Nov 12: Covered by subject & reporter for Symptom, but no "subject" for Prescription. Furthermore, we might consider adding this to the Syndrome, so as to understand what subjects are possibly affected by prescriptions.